Is Smaller Better: A Proposal To Consider Bacteria For Biologically Inspired Modeling

Bacteria are easily characterizable model organisms with an impressively complicated set of capabilities. Among their capabilities is quorum sensing, a detailed cell-cell signaling system that may have a common origin with eukaryotic cellcell signaling. Not only are the two phenomena similar, but quorum sensing, as is the case with any bacterial phenomenon when compared to eukaryotes, is also easier to study in depth than eukaryotic cell-cell signaling. This ease of study is a contrast to the only partially understood cellular dynamics of neurons. Here we review the literature on the strikingly neuron-like qualities of bacterial colonies and biofilms, including ion-based and hormonal signaling, and action potential-like behavior. This allows them to feasibly act as an analog for neurons that could produce more detailed and more accurate biologically-based computational models. Using bacteria as the basis for biologically feasible computational models may allow models to better harness the tremendous ability of biological organisms to make decisions and process information. Additionally, principles gleaned from bacterial function have the potential to influence computational efforts divorced from biology, just as neuronal function has in the abstract influenced countless machine learning efforts.